Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.

Title:

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.

identifier:	3480540
description:	epitope description:FLRGRAYGL antigen name:Epstein-Barr nuclear antigen 3 host organism:Homo sapiens t cell receptor:LC13 mhc allele name:HLA-B*35:08 Q65A, T69A, Q155A mutant
aggregation:	instance of dataset
availability:	available
primaryPublications:	20483993

study type:	t cell assays
subject species:	Human gammaherpesvirus 4

fullName:	Scott R Burrows Zhenjun Chen Julia K Archbold Fleur E Tynan Travis Beddoe Lars Kjer-Nielsen John J Miles Rajiv Khanna Denis J Moss Yu Chih Liu Stephanie Gras Lyudmila Kostenko Rebekah M Brennan Craig S Clements Andrew G Brooks Anthony W Purcell James McCluskey Jamie Rossjohn

method:	surface plasmon resonance (SPR)

name:	Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
description:	The binding of the epitope-specific LC13 TCR to the HLA-B0801/epitope complex was not affected by B0801 alpha chain single mutation Q65A, but was reduced 2- to 10-fold by mutations Q155A and T69A, respectively. Binding was abolished by the triple mutation. These residues were shown previously to form contacts with the TCR in the crystal structure.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.