Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).

Title:

Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).

identifier:	3466805
description:	epitope description:ANERADLIAYLEQATK host organism:Mus musculus t cell receptor:226 mhc allele name:H2-IEk
aggregation:	instance of dataset
availability:	available
primaryPublications:	21490152

study type:	t cell assays
subject species:

fullName:	Evan W Newell Lauren K Ely Andrew C Kruse Philip A Reay Stephanie N Rodriguez Aaron E Lin Michael S Kuhns K Christopher Garcia Mark M Davis

method:	x-ray crystallography

name:	Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
description:	The crystal structure of the epitope-specific 226 TCR bound to the analog peptide/H-2-IEk complex was solved by molecular replacement. The TCR is a chimeric fusion of 226 mouse variable domains and human constant domains. The MCC-p5E peptide was expressed tethered to the N-terminus of the TCR beta chain with a 10-residue flexible linker.

name:	iedb
homePage:	http://www.iedb.org

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