Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand.

Title:

Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand.

identifier:	3467647
description:	epitope description:LLFGYPVYV antigen name:Protein Tax-1 host organism:Homo sapiens t cell receptor:A6 mhc allele name:HLA-A*02:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	15670602

study type:	t cell assays
subject species:	Human T-lymphotropic virus 1

fullName:	Rebecca L Davis-Harrison Kathryn M Armstrong Brian M Baker

method:	surface plasmon resonance (SPR)

name:	Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand.
description:	The binding interactions of human TCR molecule A6 to the complex of HLA-A2/epitope were examined by Surface plasmon resonance (SPR). By comparison of a different TCR (B7) with similar affinity, and its binding to mutant peptide and mutant MHC complexes, it was shown that the two TCRs respond similarly to alterations in the MHC molecule but differ dramatically in their responses to ionic strength and temperature.

name:	iedb
homePage:	http://www.iedb.org

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