Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein.

Title:

Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein.

identifier:	3467747
description:	epitope description:VLGGGCALLRCIPALDSLTPANED antigen name:60 kDa heat shock protein, mitochondrial (UniProt:P10809) host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	7589082

study type:	t cell assays
subject species:	Homo sapiens

fullName:	D Elias H Marcus V Ablamunits I R Cohen

method:	in vivo assay

name:	Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein.
description:	Immunization with the epitope induced type 1 diabetes in male, but not in female mice, as measured by histology and hypoglycemia. The epitope conjugated to OVA was more effective than the epitope conjugated to BSA. Reactivity was also seen in male and female NON/Lt mice, but to a lesser amount.

name:	iedb
homePage:	http://www.iedb.org

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