Oral Immunotherapy for Childhood Egg Allergy ImmPort

ID: SDY218

Description: In the United States, as many as 6% to 8% of children are affected by food allergy. In young children, allergic reactions to egg can range from mild r...

Genotype Polymorphism effects on Typhoid Vaccine responses. ImmPort

ID: SDY22

Description: The objective is to understand role of polymorphisms in genes of innate and adaptive immunity in modulating the response to vaccines for typhoid gastr...

Genotyping and gene function in healthy volunteers ImmPort

ID: SDY25

Description: The goal of this study is to create a pool of potential subjects genotyped in a manner identical to that used in the AVA000 trial population. Subjects...

Identify polymorphisms associated with risk for the development of myopericarditis following smallpox vaccine ImmPort

ID: SDY26

Description: The overall goal of this contract is to identify genetic differences that increase the risk for a major adverse event associated with smallpox vaccina...

SWHP03 A novel pig model of Helicobacter pylori infection demonstrating Th1 and cytotoxic T cell responses ImmPort

ID: SDY262

Description: Pigs were divided into 4 groups of uninfected (n=9), infected with H. pylori strain J99 (n=9), strain SS1 (n=8) and SW-SS1 (n=9). Following a 12-hour ...

Strategies to alleviate original antigenic sin ImmPort

ID: SDY264

Description: They found that dendritic cell-activating adjuvants [Bordetella pertussis toxin (PT) or CpG ODN or a squalenebased oil-in-water nanoemulsion (NE)], up...

Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations (PROSE) ImmPort

ID: SDY1028

Description: A three-armed prospective randomized double-blind placebo-controlled trial investigating the efficacy of standard care plus 4-5 months of treatment wi...

A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data ImmPort

ID: SDY1043

Description: In this work, we present a new algorithm that employs local search techniques to discover statistically significant patient-specific motifs in large-s...

A targetable CD109-Janus kinase-Stat axis in metastatic lung cancer. ImmPort

ID: SDY1079

Description: The molecular mechanism of lung cancer metastatic remains incompletely understood. We combined tumor barcoding in a mouse model of human lung adenocar...

Project 3 - Optimization experiments DCs DV2 and DV4 - CyTOF ImmPort

ID: SDY1100

Description: Ex vivo infections of human monocyte derived DCs DENV2 and DENV4 analysis were performed to study the innate immune profile upon infection with those ...

Project 3 - Optimization experiments DCs DV2 and DV4 - MBAA ImmPort

ID: SDY1149

Description: Ex vivo infections of human monocyte derived DCs DENV2 (16681) and DENV4 (Indonesia/1976/1036) analysis were performed to study the innate immune prof...

Pediatric Kidney Transplant Without Calcineurin Inhibitors (CN01) ImmPort

ID: SDY131

Description: This protocol tests whether immunosuppression by IL-2r antibody, sirolimus, MMF, and alternate-day steroids will provide comparable graft survival for...

Tacrolimus with Steroids and Standard Daclizumab Versus Steroid-Free Tacrolimus with Extended Daclizumab in Pediatric Renal Transplantation (SNS01) ImmPort

ID: SDY132

Description: Corticosteroids have been a cornerstone of immunosuppressive therapy for kidney transplantation for over 40 years. However, poor growth and bone loss ...

Safety in Immunomodulatory Functions of Campath-1H (PC01) ImmPort

ID: SDY134

Description: Kidney transplantation is widely considered to be the treatment of choice for children with End Stage Renal Disease (ESRD). Improvements in surgical t...

Antimicrobial Response to Oral Vitamin D3 in Patients with Psoriasis ImmPort

ID: SDY14

Description: The goal of the Atopic Dermatitis and Vaccinia Network (ADVN) is to research methods for preventing atopic dermatitis (AD) subjects from contracting e...

VRC304 - A Phase I Study of the Safety and Immunogenicity of a Recombinant DNA Plasmid Vaccine (VRC-AVIDNA036-00-VP) Encoding for the Influenza Virus ... ImmPort

ID: SDY167

Description: The primary objective was to evaluate the safety and tolerability of an investigational vaccine VRC-AVIDNA036-00-VP in humans at doses 1 mg and 4 mg a...

Responses to Influenza Vaccination in Systemic Lupus Year 1 2005-2006 ImmPort

ID: SDY196

Description: Influenza is an important pathogen in the United States, with approximately 20,000 deaths per year, mainly among elderly people or those with underlyi...

Responses to Influenza Vaccination in Systemic Lupus Year 2 2006-2007 ImmPort

ID: SDY197

Description: Influenza is an important pathogen in the United States, with approximately 20,000 deaths per year, mainly among elderly people or those with underlyi...

Responses to Influenza Vaccination in Systemic Lupus Year 5 2009-2010 ImmPort

ID: SDY200

Description: Influenza is an important pathogen in the United States, with approximately 20,000 deaths per year, mainly among elderly people or those with underlyi...

Asthma Control Evaluation (ACE): A Biomarker-Based Approach to Improving Asthma Control and Mechanistic Studies ImmPort

ID: SDY210

Description: Over the past two decades, the prevalence of asthma has dramatically increased in many parts of the world. The current National Asthma Education and P...