T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2009 (See companion studies SDY315 2012 / SDY314 2008 / S...

ID: SDY312

Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum...

HLA Genetics in Pediatric Arthritis

ID: SDY313

Description: JRA (also known as JIA) includes the commonest chronic autoimmune arthropathies of childhood. The MHC is involved with respect to risk, either suscept...

Impact of immunosuppressive regimens on protective immunity in renal transplant recipients

ID: SDY33

Description: A prospective longitudinal study comparing renal transplant patients with controls to determine the biological mechanisms that underlie the immunosupp...

Responses to and control of vaccinia in immunosuppressed Rhesus Macaques

ID: SDY35

Description: A detailed mechanistic study of the immune response to vaccinia vaccine in immunosuppressed Rhesus macaques and development of a relevant preclinical ...

VZV A Study of the Safety and Effectiveness of Varivax (the Chicken Pox Vaccine) in Children Who Have Received Kidney Transplants

ID: SDY357

Description: Pediatric renal transplant patients face a lifetime of immunosuppressive therapy that places them at high risk for potentially life-threatening infect...

Systems Biology Approach to Study Influenza Vaccine 2013-14 in Healthy Children (see companion studies SDY364, SDY144, SDY387)

ID: SDY368

Description: The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the in...

Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity (Juvenile Dermatomyositis JDM) 2013/2014 Cohort (see companion studi...

ID: SDY376

Description: This Project will study vaccine responses in healthy and sick children. It will address the following questions: 1) which are the best biomarkers of p...

Delineate innate immune responses in populations at risk (the elderly and the immunosuppressed) that are different from the general population

ID: SDY40

Description: We will recruit adult (21-49 years of age), elderly (>50 years), ages as outlined in the RFA, or non-elderly but immunosuppressed (defined as taking a...

Replication and pathogenesis associated with H5N1 H5N2 and H5N3 low-pathogenic avian influenza virus infection in chickens and ducks

ID: SDY42

Description: A comparative cohort study examining replication and disease pathogenesis associated with low-pathogenic H5N1, H5N2, or H5N3 avian influenza virus (AI...

DFCI HLA typing

ID: SDY422

Description: We used an in situ synthesized DNA-based microarray method that contains thousands of probes representing a complete overlapping set covering 1,610 cl...