Systems Biology Study to Investigate Immune Correlates to Hepatitis B Vaccine Engerix-B comparing cellular responses and gene expression patterns betw...

ID: SDY690

Description: This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccinati...

Investigating Alterations to the Nasal Microbiome after Vaccination with LAIV

ID: SDY753

Description: The goal of this proposal is to characterize alterations to the nasal microbiome after vaccination with the 2012-2013 seasonal LAIV and to correlate t...

B and T Cell Determinants of Influenza Vaccine Responses in the Elderly 2009 (see companion study SDY460)

ID: SDY773

Description: Application of high-throughput DNA sequencing of the IGH gene rearrangements to study the B cell repertoires over two successive years in 27 individua...

Defective signaling in aging

ID: SDY887

Description: Pilot year. Despite the importance of the immune system in many diseases, there are currently no objective benchmarks of immunological health. In an e...

Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes

ID: ITN027AI

Description: Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks insulin-producing beta cells in the pancreas. Without these cel...

Associating Renal Transplantation With the ITN Signature of Tolerance

ID: ITN524ST

Description: This study is for people who will receive a kidney transplant from a very well matched, living blood relative. After receiving a kidney transplant, a ...

Omalizumab (Xolair) and Allergy Shots For the Treatment of Seasonal Allergies

ID: ITN019AD

Description: This Phase II double-blinded, parallel group, multi-center, placebo-controlled study examined whether pre-treatment of participants with Omalizumab fo...

Study of Tolerant Kidney Transplant Recipients

ID: ITN507ST

Description: Grant: National Institute of Allergy and Infectious Diseases This is a registry trial collecting extensive demographic and clinical information, medic...

Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children (GPAC) Study

ID: ITN025AD

Description: Researchers suspect that allergies to common inhaled allergens (such as house dust mite, cat dander, and grass pollens) are a major cause of childhood...

Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults

ID: ITN013ST

Description: Alemtuzumab (Campath-1H) is a man-made antibody used to treat certain blood disorders. The purpose of this study is to test the safety and effectivene...