T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2009 (See companion studies SDY315 2012 / SDY314 2008 / S...

ID: SDY312

Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum...

HLA Genetics in Pediatric Arthritis

ID: SDY313

Description: JRA (also known as JIA) includes the commonest chronic autoimmune arthropathies of childhood. The MHC is involved with respect to risk, either suscept...

Impact of immunosuppressive regimens on protective immunity in renal transplant recipients

ID: SDY33

Description: A prospective longitudinal study comparing renal transplant patients with controls to determine the biological mechanisms that underlie the immunosupp...

Responses to and control of vaccinia in immunosuppressed Rhesus Macaques

ID: SDY35

Description: A detailed mechanistic study of the immune response to vaccinia vaccine in immunosuppressed Rhesus macaques and development of a relevant preclinical ...

VZV A Study of the Safety and Effectiveness of Varivax (the Chicken Pox Vaccine) in Children Who Have Received Kidney Transplants

ID: SDY357

Description: Pediatric renal transplant patients face a lifetime of immunosuppressive therapy that places them at high risk for potentially life-threatening infect...

Systems Biology Approach to Study Influenza Vaccine 2013-14 in Healthy Children (see companion studies SDY364, SDY144, SDY387)

ID: SDY368

Description: The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the in...

Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity (Juvenile Dermatomyositis JDM) 2013/2014 Cohort (see companion studi...

ID: SDY376

Description: This Project will study vaccine responses in healthy and sick children. It will address the following questions: 1) which are the best biomarkers of p...

Delineate innate immune responses in populations at risk (the elderly and the immunosuppressed) that are different from the general population

ID: SDY40

Description: We will recruit adult (21-49 years of age), elderly (>50 years), ages as outlined in the RFA, or non-elderly but immunosuppressed (defined as taking a...

Replication and pathogenesis associated with H5N1 H5N2 and H5N3 low-pathogenic avian influenza virus infection in chickens and ducks

ID: SDY42

Description: A comparative cohort study examining replication and disease pathogenesis associated with low-pathogenic H5N1, H5N2, or H5N3 avian influenza virus (AI...

DFCI HLA typing

ID: SDY422

Description: We used an in situ synthesized DNA-based microarray method that contains thousands of probes representing a complete overlapping set covering 1,610 cl...

Lovastatin Therapy in Rheumatoid Arthritis

ID: SDY473

Description: This is a double-blind, placebo-controlled, randomized trial determining whether treatment with a statin reduces the serum CRP in subjects with mildly...

Characterization of the human maternal immune response 6 months or greater post delivery via cytometry Time-of-Flight(CyTOF).

ID: SDY475

Description: Preterm births occur in 12 percent of pregnancies. Preterm infants are at risk for long term health problems such as impaired hearing and vision, cere...

GPAC ITN025AD: Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children

ID: SDY545

Description: Researchers suspect that allergies to common inhaled allergens (such as house dust mite, cat dander, and grass pollens) are a major cause of childhood...

STAyCIS ITN020AI: Atorvastatin (Lipitor) Therapy in Patients with Clinically Isolated Syndrome (CIS) at Risk for Multiple Sclerosis

ID: SDY547

Description: CIS is a single clinical event indicating temporary disruption of normal nerve function. CIS patients may have a loss of vision in one eye; trouble wi...

Immune Responses to Seasonal TIV 2012-2013 Influenza Vaccination in Humans (see companion study SDY396,SDY224)

ID: SDY564

Description: To use system biology approaches to compare differences in immune responses to vaccine

Orban ITN012AI: Evaluation of Diabetes Vaccine IBC-VSO1 in Newly Diagnosed Diabetics

ID: SDY568

Description: This study will evaluate whether IBC-VSO1 vaccine, a synthetic metabolically inactive form of insulin designed to prevent pancreatic beta-cell destruc...

Observational Study of Alloimmunity in Cardiac Transplant Recipients (CTOT-05)

ID: SDY571

Description: A major cause of heart transplant failure is the blockage of blood flow from lesions caused by ongoing injury and repair of the graft by the host's im...

Host responses to Enteroaggregative Escherichia coli (EAEC) infection

ID: SDY572

Description: Enteroaggregative Escherichia coli (EAEC) is increasingly recognized as a major cause of diarrheal disease globally. In the current study, we investig...

2013 Murine Vaccine with Adjuvant Study

ID: SDY585

Description: Study of Influenza vaccine coupled with adjuvant in Murine model

Zinc and tryptophan effects on immunology

ID: SDY588

Description: WT mice fed either nourished or RBD-Zn diet for two weeks. +/- antibiotic pre-Rx then 042wt infected to determine effect of antibiotics in model.

HP47

ID: SDY601

Description: WT and PPARgfl/fl:LysCre+ (R2+) mice were infected with 5x10e7 CFU of different Helicobacter pylori strains (26695, SS1 and PMSS1). A control uninfect...

ADRN Influenza Vaccine Pilot (ADRN-03)

ID: SDY618

Description: This is a single center, open-label, mechanistic study designed to determine the variance of the antibody response in non-atopic and ADEH- participant...

Immunologic and genomic signatures of influenza vaccine response - 2010 (see companion studies SDY400, SDY404, SDY520)

ID: SDY63

Description: Project 1: Immunologic and genomic signatures of influenza vaccine response.

Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.

ID: SDY649

Description: Naive T cell responses are eroded with aging. We and others have recently shown that unimmunized old mice lose ? 70% of Ag-specific CD8 T cell precurs...

WNV induces pro-apoptotic miRNA

ID: SDY651

Description: MicroRNAs (miRNAs) are a class of noncoding small RNAs that regulate multiple cellular processes, as well as the replication and pathogenesis of many ...

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.

ID: SDY654

Description: Aging of the world population and a concomitant increase in age-related diseases and disabilities mandates the search for strategies to increase healt...

LEAP ITN032AD: Induction of Tolerance through Early Introduction of Peanut in High-Risk Children, LEAP-On ITN049AD: The Persistence of Oral Tolerance ...

ID: SDY660

Description: ITN032AD: Allergic reactions to peanuts are potentially life-threatening and, in some children, can result from ingestion of only trace quantities of ...

The immune signature of palmoplantar pustulosis

ID: SDY667

Description: This study will compare adult patients with CPP(chronic plaque type psoriasis ), who are currently not undergoing topical, systemic or biologic treatm...

Systems scale interactive exploration reveals quantitative and qualitative differences in response to 2009-2010 Fluzone influenza vaccine and pneumoco...

ID: SDY180

Description: Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-...

Immune Responses to Seasonal TIV 2010-2011 Influenza Vaccination in Humans (see companion study SDY396,SDY564)

ID: SDY224

Description: High-frequency sampling combined with systems biology analysis of human peripheral blood cells following influenza vaccination was used to investigate...

Determinants of human NK cell diversity by mass cytometry

ID: SDY232

Description: Natural Killer (NK) cells play critical roles in immune defense and reproduction, yet remain the most poorly understood lymphocyte population. Because...

Simulation and Prediction of the Adaptive Immune Response and Quantification of Early and Adaptive Immune Response Kinetics to Influenza A Virus Infec...

ID: SDY241

Description: Seasonal and pandemic influenza A virus (IAV) continues to be a public health threat. Modeling approaches were used combined with experimental data to...

T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2009 (See companion studies SDY315 2012 / SDY314 2008 / S...

ID: SDY312

Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum...

T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2012 (See companion studies SDY311 2010 / SDY312 2009 / S...

ID: SDY315

Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum...

Systems Biology Approach to Study Influenza Vaccine 2010-11 in Healthy Children (see companion studies SDY144, SDY368, SDY387)

ID: SDY387

Description: The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the in...

Study to measure the immune response to the influenza vaccine in patients with chronic plaque psoriasis

ID: SDY416

Description: Interleukin-12 (IL-12) and interleukin-23 are heterodimeric cytokines, with a common p40 subunit and a unique chain (IL-12p35 and IL-23p19). The p40 ...

Monozygotic and Dizygotic Twin Pair T-Cell Responses to Influenza Vaccination 2010

ID: SDY515

Description: Evaluate the variation in immune response between individuals and assess whether it changes as a function of age and similarity in genetic and environ...

Natural Killer cells in resistance to infection with West Nile virus

ID: SDY517

Description: Examine the response of primary NK cells from subjects with a history of asymptomatic or severe infection with West nile virus

Monozygotic and Dizygotic Twin Pair T-Cell Responses to Influenza Vaccination 2011

ID: SDY519

Description: Evaluate the variation in immune response between individuals and assess whether it changes as a function of age and similarity in genetic and environ...

Immunologic and genomic signatures of influenza vaccine response - 2014

ID: SDY640

Description: Project 1: Immunologic and genomic signatures of influenza vaccine response - year5 2014

Systems Biology Study to Investigate Immune Correlates to Hepatitis B Vaccine Engerix-B comparing cellular responses and gene expression patterns betw...

ID: SDY690

Description: This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccinati...

Investigating Alterations to the Nasal Microbiome after Vaccination with LAIV

ID: SDY753

Description: The goal of this proposal is to characterize alterations to the nasal microbiome after vaccination with the 2012-2013 seasonal LAIV and to correlate t...

B and T Cell Determinants of Influenza Vaccine Responses in the Elderly 2009 (see companion study SDY460)

ID: SDY773

Description: Application of high-throughput DNA sequencing of the IGH gene rearrangements to study the B cell repertoires over two successive years in 27 individua...

Defective signaling in aging

ID: SDY887

Description: Pilot year. Despite the importance of the immune system in many diseases, there are currently no objective benchmarks of immunological health. In an e...

Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes

ID: ITN027AI

Description: Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks insulin-producing beta cells in the pancreas. Without these cel...

Associating Renal Transplantation With the ITN Signature of Tolerance

ID: ITN524ST

Description: This study is for people who will receive a kidney transplant from a very well matched, living blood relative. After receiving a kidney transplant, a ...

Omalizumab (Xolair) and Allergy Shots For the Treatment of Seasonal Allergies

ID: ITN019AD

Description: This Phase II double-blinded, parallel group, multi-center, placebo-controlled study examined whether pre-treatment of participants with Omalizumab fo...

Study of Tolerant Kidney Transplant Recipients

ID: ITN507ST

Description: Grant: National Institute of Allergy and Infectious Diseases This is a registry trial collecting extensive demographic and clinical information, medic...

Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children (GPAC) Study

ID: ITN025AD

Description: Researchers suspect that allergies to common inhaled allergens (such as house dust mite, cat dander, and grass pollens) are a major cause of childhood...

Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults

ID: ITN013ST

Description: Alemtuzumab (Campath-1H) is a man-made antibody used to treat certain blood disorders. The purpose of this study is to test the safety and effectivene...

Using Donor Stem Cells and Alemtuzumab to Prevent Organ Rejection in Kidney Transplant Patients

ID: ITN022ST

Description: Alemtuzumab (Campath-1H) is a man-made antibody used to treat certain blood disorders. This study will evaluate treatment of kidney transplant recipie...

Atorvastatin (Lipitor) Therapy in Patients With Clinically Isolated Syndrome (CIS) at Risk for Multiple Sclerosis

ID: ITN020AI

Description: This is a phase II, double blind, placebo-controlled, multicenter, randomized study of the efficacy and safety of atorvastatin (80 mg/day) in particip...

Withdrawal of Immunosuppression in Pediatric Liver Transplant Recipients

ID: ITN029ST

Description: This is a prospective multicenter, open-label, single-arm trial in which 20 pediatric recipients of parental living-donor liver allografts will underg...