A Cooperative Clinical Study of Abatacept in Multiple Sclerosis ITN TrialShare

ID: ITN035AI

Description: Background and Introduction Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal T-cell and ...

High Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis ITN TrialShare

ID: ITN033AI

Description: This study is a prospective, multicenter Phase II clinical trial evaluating high-dose immunosuppressive therapy (HDIT) using Carmustine, Etoposide, Cy...

Proleukin and Rapamune in Type 1 Diabetes ITN TrialShare

ID: ITN018AI

Description: At the time of diagnosis with type 1 diabetes, 15-40% of beta cells may remain active and healthy in the pancreas, capable of producing insulin the bo...

Safety of RG2077 in Patients With Multiple Sclerosis ITN TrialShare

ID: ITN006AI

Description: This is an open-label, dose escalation, safety study. An initial group of 16 subjects who are diagnosed with relapsing-remitting MS will be enrolled o...

LEAP: Induction of Tolerance through Early Introduction of Peanut in High-Risk Children ITN TrialShare

ID: ITN032AD

Description: This is a randomized controlled trial in which children at high risk for peanut allergy (as demonstrated by eczema, egg allergy, or both) are enrolled...

Long-Term Effects of Sublingual Grass Therapy ITN TrialShare

ID: ITN043AD

Description: An estimated 45 million people in Europe have allergic rhinitis due to grass pollen allergy. Quality of life is often adversely affected by this condi...

Treatment With hOKT3gamma1(Ala-Ala) in T1DM ITN TrialShare

ID: ITN007AI

Description: This is a 2-arm, open-label Phase II trial involving 0 or 3 cycles of treatment, 6 months apart, with hOKT3γ1(Ala-Ala), over the first year of diseas...

Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis ITN TrialShare

ID: ITN021AI

Description: Current conventional therapies for ANCA-associated vasculitis (AAV) are associated with high incidences of treatment failure, disease relapse, substan...

Islet Transplantation for Type 1 Diabetes ITN TrialShare

ID: ITN005CT

Description: This is a single-arm, Phase I study, the primary objective of which is to cure diabetes mellitus by an injection of cellular graft into the liver. The...

Inducing Remission in Type 1 Diabetes With Alefacept ITN TrialShare

ID: ITN045AI

Description: The primary objective of this trial is to determine whether alefacept will slow the progression of the autoimmune destruction of β cells and lead to ...

Belatacept to Prevent Organ Rejection in Kidney Transplant Patients ITN TrialShare

ID: ITN023ST

Islet Transplantation in Type 1 Diabetes ITN TrialShare

ID: CIT-07

Description: Type 1 diabetes is commonly treated with the administration of insulin, either by multiple insulin injections or by a continuous supply of insulin thr...

Evaluation of a Diabetes Vaccine in Newly Diagnosed Diabetics ITN TrialShare

ID: ITN012AI

Description: This is a randomized, double-masked, 2-arm pilot study to monitor the safety of human insulin B-chain (IBC) peptide (BB-IND 8884) in subjects with typ...

Treating Systemic Lupus Erythematosus (SLE) Patients With CTLA4-IgG4m (RG2077) ITN TrialShare

ID: ITN002AI

Description: This trial comprises a dose-escalation portion and a randomized, controlled, open-label phase IIA portion that evaluate a single dose of CTLA4-IgG4m (...

Development of antigen-specific assays indicative of donor-specific tolerance in renal transplant recipients ITN TrialShare

ID: ITN503ST

Description: This study will attempt to establish the optimal (reproducibility and utility) in vitro assay/s for quantification and characterization of anti-donor ...

Evaluation of Tolerability, Safety, and Pharmacokinetics of hOKt3γ1 (Ala-Ala) in Participants with Type 1 Diabetes Mellitus ITN TrialShare

ID: ITN017AI

Description: This study evaluated the safety and pharmacokinetics (PK) of hOKt3γ1 (Ala-Ala) in participants with Type 1 diabetes mellitus. A first group of 4 part...

Persistence of Oral Tolerance to Peanut ITN TrialShare

ID: ITN049AD

Description: ITN049AD (LEAP-On) is a continuation of the ITN032AD LEAP Study. Peanut Allergy, a recognized public health concern, is a common and potentially life-...

Treatment of Psoriatic Arthritis with hOKT3γ1 (Ala-Ala) ITN TrialShare

ID: ITN011AI

Description: Of the two currently available treatments for kidney failure, long-term dialysis and kidney transplantation, only kidney transplantation provides a po...

Study of Antithymocyte Globulin for Treatment of New-onset T1DM ITN TrialShare

ID: ITN028AI

Description: This is a two-arm, 2:1 randomized, placebo-controlled, blinded, phase II trial. The clinical outcome variable proposed for clinical protocol ITN028AI ...

Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes ITN TrialShare

ID: ITN027AI

Description: Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks insulin-producing beta cells in the pancreas. Without these cel...